| Name | Angiotensin (1-7) acetate |
| Description | Angiotensin (1-7) acetate (Ang-(1-7) acetate) is an amino acid sequence present in angiotensin, which has antifibrotic and cardioprotective effects and inhibits the activity of purified canine angiotensin converting enzyme (ACE). Angiotensin (1-7) acetate inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer, blocks angiotensin II-induced smooth muscle cell proliferation and hypertrophy, and can be used to study atherosclerosis and novel coronavirus infection. |
| In vitro | Pretreatment with Angiotensin (1-7) acetate (2 μM) significantly inhibited the degradation of 125I-[Tyr0]-BK as well as the appearance of BK-(1-7) and BK-(1-5) metabolites in the coronary vascular ring; Angiotensin (1-7) acetate inhibited the angiotensin-converting enzyme activity of purified canine angiotensin converting enzyme with an IC50 of 0.65 μM.[2] |
| In vivo | METHODS: Angiotensin (1-7) acetate (0.01-0.06 mg/kg,daily) was used to treat DSS-induced colitis mice, and colonic expression/activity profiles of ACE2, Ang 1-7, MAS1-Receptor (MAS1-R), MAPK family and Akt were determined by western blotting and immunofluorescence.
RESULTS: Enhanced colonic expression of ACE2, Ang 1-7, and MAS1-R was observed in mice after Angiotensin (1-7) acetate treatment and significantly ameliorated DSS-induced colitis. [3] |
| Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. |
| Solubility Information | H2O : 50 mg/mL（52.13 mM), Sonication is recommended.
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| Keywords | Angiotensin | Angiotensin (1 7) (acetate) | Angiotensin (17) (acetate) |
| Inhibitors Related | Olmesartan Medoxomil | Tranilast | Enalapril Maleate | Azilsartan Methyl Ester | Sacubitril/Valsartan | Azilsartan | Sinapinic Acid | Irbesartan | Losartan | Ramipril | Captopril | Valsartan Methyl Ester |
United States
