| Name | Anandamide |
| Description | Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system. |
| In vitro | Anandamide, acting via CB2 receptors, alleviates lipopolysaccharide (LPS)-induced neuroinflammation in rat primary microglial cultures. Endocannabinoids, especially Anandamide (AEA), can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55 [1]. |
| In vivo | Anandamide is an endocannabinoid binding both CB1R and CB2R. To evaluate the impact of CBR activation on whole-body glucose homeostasis, glucose tolerance is assessed after a single intraperitoneal Anandamide injection (10 mg/kg). The increase in glycemia in response to glucose ingestion is considerably smaller in mice treated with Anandamide compared with control. It is associated with an improvement of glucose tolerance as illustrated by the AUC0-2h calculations[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 10 mg/mL (28.77 mM)
DMSO : 55 mg/mL (158.26 mM)
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| Keywords | Transient receptor potential channels | Inhibitor | inhibit | Alzheimer’s disease | Candida albicans | anti-fungal | anti-adhesive | cervical epithelial cells | Endogenous Metabolite | G protein-coupled receptor 55 | Streptozotocin | hVSMC | N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | HeLa cells | GPR55 | TRP Channel | Anandamide | Cannabinoid Receptor | endocannabinoid | Peroxisome proliferator-activated receptors | Fungal | PPAR | Tau Protein |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Natural Product Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | GPCR Compound Library | Human Metabolite Library |
United States
