| Name | Allethrin |
| Description | Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. |
| In vitro | Allethrin (125 μM) induces BCL-2, caspase-3 activation and release of intracellular calcium[1]. Morphological analyses of LC540 cells treated with Allethrin (125 μM) reveals the presence of apoptotic bodies. The percentage of cells displaying early apoptotic features increased significantly[1]. |
| In vivo | In male wistar rats aged 90 day,s Allethrin (25, 50, 100, and 150 mg/kg; every day for 60 days) increased lipid peroxidation in the caput, cauda, and testes[3]. Significant increase in catalase activity was observed in the cauda obtained from 50, 100, and 150 mg/kg. GPx activity was significantly increased in the caput obtained from 150 mg/kg treated rats. In the cauda, it was found to be increased significantly in the 50 and 100 mg/kg treated groups. In contrast, the activity of GPx activity was significantly decreased in the testes of rats treated with 150 mg/kg. GST activity was found to be increased significantly in a dose dependent manner in the caput and cauda of allethrin treated rats[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/ml (198.41 mM)
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| Keywords | mosquito | calcium | release | Allethrin | sperm | maturation | insecticide | inhibit | Apoptosis | repellent | epididymis | Pyrethroid | stress | Inhibitor | testis | oxidative |
| Inhibitors Related | Taurodeoxycholic acid | (S)-(+)-Ibuprofen | SKLB-163 | Navitoclax | Gossypol | Taurochenodeoxycholic Acid | Tauroursodeoxycholate sodium | Lisaftoclax | Venetoclax | Metaldehyde | Tauroursodeoxycholate | PAC-1 |
| Related Compound Libraries | Cuproptosis Compound Library | Pesticide Compound Library | Bioactive Compound Library | Pyroptosis Compound Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
