Name | Alclometasone dipropionate |
Description | Alclometasone dipropionate (Sch 22219) is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation. |
In vitro | The suppressive effect of tacrolimus on cytokine production was stronger than that of alclometasone dipropionate and equal to or stronger than that of betamethason valerate. The effective dose of tacrolimus (IC50, 0.02-0.11 ng/ml) is almost the same as for Th1 and Th2 cytokines, and 1 ng/ml of tacrolimus suppressed all cytokines completely[1]. |
In vivo | In Lewis rats with tuberculin-induced delayed-type hypersensitivity reaction, alclometasone dipropionate (0.1% (20μL, administered once to the ear) partially inhibited the increase in dye leakage, indicating its impact on hypersensitivity reactions induced by tuberculin and ovalbumin [2]. |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : Insoluble DMSO : 5 mg/mL (9.60 mM), Sonication is recommended.
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Keywords | Almeta | Alclometasone |
Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |