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ChemicalBook Product Catalog API Antibiotics Other antibiotic Drugs Albaconazole

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Albaconazole NEW

$350.00 1mg

$828.00 5mg

$1130.00 10mg

Min. Order
Purity100%
Cas No187949-02-6
Supply Ability10g
Update time2024-11-17

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Albaconazole
CAS No	187949-02-6
EC-No
Min. Order
Purity	100%
Supply Ability	10g
Release date	2024/11/17

Product Introduction

Bioactivity

名称	Albaconazole
描述	Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, skin and musculoskeletal disorders, and can be used in the study of vulvovaginal candidiasis, Chagas disease and genitourinary disorders.
体内活性	Forty participants were enrolled in this Phase I, open-label, two-sequence crossover study. Twenty participants were exposed to a single 400-mg tablet dose of albaconazole before being crossed over to a single dose of four 100-mg albaconazole capsules. The second group of 20 participants received the study products in reverse order. Blood samples were taken over 15 days post-dose to assess the plasma concentrations and pharmacokinetic parameters of albaconazole and its primary metabolite, 6-hydroxyalbaconazole. Safety was assessed throughout the study. The area under the curve (AUC) and maximum measured plasma concentration (C(max)) of the albaconazole tablet were approximately 10% and 22% lower, respectively, than for the albaconazole capsules. Statistical significance was reached for the C(max) but not for the AUC measurements (AUC(0-t) and AUC(0-inf)). Because the 90% confidence intervals based on the differences between the tablet and capsule were outside the 80%-125% range for both the C(max) and AUC, we concluded that the formulations were not bioequivalent with respect to the rate or extent of absorption. The AUC and C(max) of albaconazole after a single 400-mg oral dose administered as a tablet formulation were lower than those of a capsule formulation. Albaconazole tablets and capsules cannot, therefore, be considered bioequivalent.[1]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 55 mg/mL (127.37 mM)
关键字	Albaconazole \| W0027 \| UR 9825
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相关库	经典已知活性库 \| 抗真菌库 \| 药物功能重定位化合物库 \| 抑制剂库 \| 抗衰老化合物库 \| 临床期小分子药物库 \| 已知活性化合物库

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