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ChemicalBook Product Catalog Akt1 and Akt2-IN-1

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Akt1 and Akt2-IN-1 NEW

$347.00 5mg

$1140.00 25mg

$1490.00 50mg

Min. Order
Purity
Cas No893422-47-4
Supply Ability10g
Update time2025-07-22

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	Akt1 and Akt2-IN-1
CAS No	893422-47-4
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2025/07/22

Product Introduction

Bioactivity

Name	Akt1 and Akt2-IN-1
Description	Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). It has potent and balanced activity.
In vitro	Akt1 and Akt2-IN-1 (Compound 17) has moderate activity in an hERG binding assay (IC50=5610 nM) and is a substrate for human P-glycoprotein[1]. Consistent with the allosteric mode of inhibition, Akt1 and Akt2-IN-1 (Compound 17) is dependent on the PH-domain for Akt inhibition. Akt1 and Akt2-IN-1 (Compound 17) is selective for Akt1/2 over Akt3 (IC50=1900 nM), and is highly selective over other members of the AGC family of kinases (>50 μM vs PKA, PKC, SGK).
In vivo	Akt1 and Akt2-IN-1 (Compound 17) is well tolerated in at exposures that provide high levels of Akt1 and 2 inhibition in vivo. Akt1 and Akt2-IN-1 (Compound 17) shows good pharmacokinetics in rat with a low clearance of 4.6 mL/min/kg and a half-life of 3.8 h. Due to the improved cell potency, physical properties, and rodent pharmacokinetics of Akt1 and Akt2-IN-1 (Compound 17), tolerability and Akt inhibition are assessed in mice. Akt1 and Akt2-IN-1 (Compound 17) has also been shown to inhibit the growth of A2780 tumors in vivo when used as monotherapy and has potent inhibitory activity against Akt1 and 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. Using an acute dosing schedule (IP dosing of 50 mg/kg at times 0, 3, and 8 h), administration of Akt1 and Akt2-IN-1 (Compound 17) is well tolerated in mice and shows high levels of Akt inhibition in mouse lung[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 35 mg/mL (64.86 mM), Sonication is recommended.
Keywords	Akt2 \| Akt1 and Akt2-IN-1 \| Akt-1 and Akt2-IN-1 \| Akt1 and Akt2IN1 \| Akt1 and Akt2 IN 1 \| Akt1
Inhibitors Related	Ethyl gallate \| Oridonin \| Capivasertib \| SKLB-163 \| Scutellarin \| Methyl-Hesperidin \| Artemisinin \| Honokiol \| (E)-Akt inhibitor-IV \| 2,3-Butanediol \| MK-2206 dihydrochloride \| AKT Kinase Inhibitor

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