| Name | ADH-503 |
| Description | ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist that can lead to repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhancement of dendritic cell responses. |
| Animal Research | Animal Model:Male rats.Dosage:30,100 mg/kg (Pharmacokinetic Analysis). Administration:Oral gavage twice a day; on days 1 and 5 |
| In vitro | METHODS: ADH-503 (GB1275) (4 μM, 10 days) was used to investigate the expression of macrophage markers in two syngeneic orthotopic models.
RESULTS After treatment with ADH-503 (GB1275), macrophages expressed higher levels of MHCI, MHCII, CD80, and CD86, indicating improved antigen presentation properties of the remaining macrophages. [1] |
| In vivo | METHODS: ADH-503 (GB1275) (30, 100 mg/kg, oral) was administered to rats and C57/B6 mice to test the pharmacokinetics (PK) and safety.
RESULTS The mean half-life of ADH-503 (GB1275) in rats and mice after administration was 4.68 and 3.95 hours, and the Cmax and AUC0-t in plasma were 1716 and 2594 ng/mL and 6950 and 13962 ng.h/mL, respectively. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5.25 mg/mL (10 mM)
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| Keywords | tumor-infiltrating | ADH-503 | ADH 503 | CD11b | GB 1275 | Inhibitor | tumorassociated | dendritic | immunosuppressive | ADH503 | macrophages | repolarization | allosteric | inhibit | Complement System | orally | GB-1275 |
| Inhibitors Related | EG01377 2HCl | Iptacopan hydrochloride | SB290157 trifluoroacetate | LEP(116-130)(mouse)TFA(258276-95-8 free base) | BCX 1470 hydrochloride | Complement C5-IN-1 | CP-289 | Dexamethasone | CP-447697 | Complement factor D-IN-2 | Cyclosporin A | 3-Phenoxybenzaldehyde |
| Related Compound Libraries | Bioactive Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
