| Name | Adenosine |
| Description | Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects. |
| In vitro | METHODS: Human prostate cancer cells DU-145, PC3 and LNcap-FGC-10 were treated with Adenosine (0.1-1000 µM) for 48 h. Cell viability was measured by MTT assay.
RESULTS: Adenosine significantly reduced cell proliferation of DU-145, PC3 and LNcap-FGC10 cell lines in a dose-dependent manner. [1]
METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Adenosine (2 mM) for 6-24 h. The cell cycle was detected by Flow cytometry.
RESULTS: Adenosine-induced inhibition of survival was attributed to the arrest of cell cycle progression. Adenosine significantly increased the percentage of G0/G1-phase cells and decreased the percentage of S-phase and G2/M-phase cells in HepG2 cells. [2] |
| In vivo | METHODS: To investigate the antidepressant-like effects, Adenosine (1-10 mg/kg) was intraperitoneally injected into mice and subjected to the forced swimming test (FST) and tail suspension test (TST).
RESULTS: The immobilization time in the FST was shortened by intraperitoneal injection of Adenosine (5-10 mg/kg), and Adenosine (1-10 mg/kg) also produced antidepressant-like effects in the TST. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 5% DMSO+95% Saline : 1.05 mg/mL (3.93 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 20 mg/mL (74.84 mM), Sonication is recommended.
H2O : 2.7 mg/mL (10.1 mM), Sonication is recommended.
10% DMSO+90% Saline : 2 mg/mL (7.48 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
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| Keywords | vascular | regulation | platelet | NucleosideAntimetabolite | Nucleoside Antimetabolite/Analog | Nucleoside Antimetabolite | Nucleoside | neuronal | Inhibitor | inhibit | GPCR | EndogenousMetabolite | Endogenous Metabolite | endogenous | cell | blood | Autophagy | Apoptosis | Analog | aggregation | Adenosine |
| Inhibitors Related | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Fumaric acid | Tributyrin | Ferulic Acid | Formamide | Paeonol | Glycerol | Thymidine | 3-Indoleacetic acid |
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