1. Materials information
Names
| Name | Ademetionine 1,4-butanedisulfonate |
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| Synonym | More Synonyms |
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Ademetionine 1,4-butanedisulfonate Biological Activity
| Description | SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders[1][2][3][4]. |
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| Related Catalog | Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease |
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| In Viv | Animal Model: Mice submitted to the forced swimming test (FST) and tail suspension test (TST)[4] Dosage: 10, 255, 50, 100, 200 mg/kg Administration: i.p. Result: Reduced the immobility time in the FST and reduced the total distance traveled. |
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| References | [1]. Delle Chiaie R, et al. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002 Nov;76(5):1172S-6S. [2]. Barceló HA, et al. Osteoartritis experimental y su evolución bajo tratamiento con S-adenosil-L-metionina (SAMe) [Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine]. Rev Clin Esp. 1990 Jun;187(2):74-8. Spanish. [3]. Stramentinoli G, et al. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem Pharmacol. 1978 May 15;27(10):1431-3. [4]. Sales AJ, et al. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochem Int. 2023 Jan;162:105442. |
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Chemical & Physical Properties
| Melting Point | 125-135°C |
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| Molecular Formula | C42H74N12O28S8 |
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| Molecular Weight | 1451.621 |
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| Exact Mass | 1450.250122 |
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| PSA | 798.02000 |
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| LogP | 3.14480 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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