名称 | Adapalene |
描述 | Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
体外活性 | In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes. |
体内活性 | In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis. |
存储条件 | keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 1 mg/ml, Sonication is recommended.
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关键字 | RAR/RXR | GOT1 | acne | RARα | Adapalene | Autophagy | Retinoid X receptors | CD 271 | Inhibitor | RARγ | tumor | retinoid | Apoptosis | RAR | CD-271 | Retinoic acid receptors | RARβ | inhibit |
相关产品 | Stavudine | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Tributyrin | Paeonol | Naringin | Salicylic acid | Gefitinib | Oleic acid |
相关库 | 经典已知活性库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | NO PAINS 化合物库 | 抗癌上市药物库 | FDA 上市药物库 | 口服活性化合物库 | 免疫/炎症分子化合物库 | 已知活性化合物库 | 抗感染化合物库 | 抗癌活性化合物库 | 抗癌药物库 |