| Name | Acoramidis hydrochloride |
| Description | Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis. |
| In vitro | Acoramidis (AG10, 0.1-10 μM for TTR ～5 μM) stabilizes V122I- and WT-TTR effectively, outperforming their efficacy in whole serum [1]. Acoramidis (AG10) stimulates mitochondrial QO2 concentration-dependently between 10 and 100 μM [3]. It exhibits minimal inhibition of the potassium ion channel hERG (IC50 > 100 μM) and several cytochrome P450 isozymes (IC50 > 50 μM) [low toxicity] [1]. Western Blot Analysis [1], using human serum (TTR ～5 μM), at concentrations of 0.1 and 10 μM, with a 72-hour incubation, shows AG10 is significantly more effective than tafamidis in stabilizing TTR, with 10 μM stabilizing almost all TTR in serum. |
| In vivo | Animal Model: Wistar rats [1] . Dosage: 50 mg/kg/d (Toxicity Analysis). Administration: Oral gavage, daily for 28 d. Result: Showed the plasma C max of ～40 μM and histopathological evaluation of liver, kidney, heart, spleen, thymus, and lung showed no signs of pathologic processes in the Acoramidis-treated animals |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.08 mM), Sonication is recommended.
DMSO : 60 mg/mL (182.5 mM), Sonication is recommended.
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| Keywords | Transthyretin | Alxn2060 Hydrochloride | AG-10 Hydrochloride | AG10 Hydrochloride | AG 10 Hydrochloride | Acoramidis Hydrochloride |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
United States
