Acarbose
CAS: 56180-94-0
Certifications: ISO 9001:2015; GMP
Specs:USP-40
Appearance: White Powder
Description
Acarbose is a C7N-amino cyclitol pseudotetrasaccharide that competitively inhibits α-glucosidase and is widely used in the treatment of Type II diabetes. It helps reduce postprandial hyperglycemia in diabetic patients by delaying glucose absorption.
Clinical Applications
Acarbose, derived from actinomycetes cultures, is a complex oligosaccharide and a widely used first-line oral antidiabetic medication. It works by binding to intestinal α-glucosidase, inhibiting its activity, and slowing the breakdown of carbohydrates such as starch, sucrose, lactose, maltose, and dextrin. This delays glucose absorption and lowers postprandial blood glucose levels, indirectly reducing fasting blood glucose and urinary glucose. Additionally, acarbose can aid in weight loss, reduce blood pressure and triglyceride levels, and lower the risk of cardiovascular disease with long-term use. It is particularly suitable for Type II diabetes patients whose diets are rich in carbohydrates or those with elevated postprandial blood glucose levels.
Storage and Handling
Store in a ventilated, low-temperature, and dry environment.
Production Advantages
Our research team has conducted comparative genomic analysis to uncover the mechanisms for high-yield acarbose production. Through targeted gene knockouts, we have eliminated major byproducts such as Component C and significantly enhanced acarbose yield using an "open source and reduce expenditure" strategy, resulting in a stable, high-yield production strain.
Side Effects
Common side effects include gastrointestinal disturbances such as bloating, diarrhea, and abdominal pain, caused by bacterial fermentation of unabsorbed sugars in the colon due to impaired carbohydrate digestion and absorption in the small intestine. Rarely, it may cause hepatocellular liver injury, including jaundice and elevated transaminase levels, which subside upon discontinuation. Allergic and skin reactions are uncommon.
Uses
Acarbose is an oligosaccharide that reversibly inhibits the activity of α-glucosidase in the brush border of the small intestinal mucosa, slowing the digestion of complex polysaccharides and sucrose. This delays glucose absorption and is commonly used for treating both insulin-dependent and non-insulin-dependent diabetes.
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