| Name | A-804598 |
| Description | A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). |
| In vitro | A-804598 effectively blocked IL-1β release in the THP-1 cells (IC50: 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50: 8.1 nM) with similar potency as in the calcium-influx assay. [1] |
| In vivo | According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughout the rat brain. In the grey matter of the L4-L6 region of the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 31.5 mg/mL (99.88 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.34 mM), Sonication is recommended.
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| Keywords | P2XRs | P2XReceptor | P2X7 | P2X Receptor | Inhibitor | inhibit | A-804598 | A804598 |
| Inhibitors Related | Gefapixant citrate | Eperisone hydrochloride | Aurintricarboxylic acid | Sodium metatungstate | NP-1815-PX | (E/Z)-Sivopixant | PSB-12062 | ATP disodium salt | Oxatomide | Ivermectin | Lappaconitine | Paroxetine |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
United States
