Pomalidomide NEW

Factory Provide 99% Purity CAS 19171-19-8 Pomalidomide API

Introduction

Product Name : Pomalidomide

Other name:4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;Pomalidomide;Pomalidomide(CC-4047);ActiMid;3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide

CAS No.:19171-19-8

MF:C13H11N3O4

Purity :99%

MW:273.24

Melting Point :318.5 - 320.5°C

Boiling Point :582.9±45.0 °C(Predicted)

Density :1.570±0.06 g/cm3(Predicted)

Appearance: white to yellow powder

Storage :Sealed in dry,Sealed in dry,Room Temperature

Pomalidomide is an orally bioavailable derivative with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.

Application 

Pomalidomide is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion of the last therapy.