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DOTA Usage And Synthesis

Chemical Properties Colourless crystals

Uses 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.

DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.

It can form complexes with gadolinium for application as MRI contrast agents.

Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Uses Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.

Definition ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.