ivermectin

_{Formula: C48H74O14}

_{Molecular Weight: 875.11}

_{CAS: 70288-86-7}

_{EINECS: 274-536-0}

_{IVERMECTIN is a white crystalline powder;Tasteless.This product in methanol, ethanol, acetone, ethyl acetate easily dissolved, almost insoluble in water}

_{Ivermectin is a new kind of broad spectrum, high efficiency, low toxicity antibiotic drug resistant parasites, external parasite especially are good flooding kill nematodes and arthropods, widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod, canine intestinal nematodes, ear mites, scabies mites, heart silk worm and microfilariae, gastrointestinal nematodes and external parasites, and poultry.}

2.  1 Ivermectin is the derivatives of abamectin. Ivermectin belongs to oral semisynthetic broad-spectrum drug resistant parasites.

4.  2 Ivermectin has effect for most of the various life cycle nematodes.

6.  3 Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus

8.  4 Ivermectin has effect for dung round worms that is only stay in intestinal tract

10.  5 Ivermectin has selective inhibition.

12.  6 Ivermectin can not go through the blood brain barrier of humanbeings

14. Specification
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    Product Name

    Ivermectin

    Quantity

    200.00kg

    Appearance

    White or yellowish-white crystalline powder

    Solubility

    Practically insoluble in water, freely soluble immethylene chloride,soluble in alcohol.

    Identification

    A:Melting range 168-172℃

    IR

    Corresponds with that of CRS standard

    HPLC

    The retention time for H2B1a and H2B1b corresponds with that of standard preparation

    Appearance of solution

    Clear and not more intensely colored than BY1

    Specific optical rotation(anhydrous and solvent-free substance)

    -17 ~ -20

    Related substances

    Individual impurity(RRT1.3-1.5)≤2.5

     

    Any other individual impurity≤1

     

    Total ≤5

     

    Disregard limit≤0.05

    Ethanol and Formamide(%)

    Ethanol≤5.0

     

    Formamide≤3.0

    Heavy metal(%)

    ≤0.002

    Water(%)

    ≤1.0

    Sulphated ash(%)

    ≤0.1

    Residue of solvent(toluene)

    ≤890ppm

    Assay(%)(HPLC,on dry basis)

    H2B1a(H2B1a+H2B1b)≥90.0

     

    95.0≤H2B1a+H2B1b≤102.0