Glyceryl Behenate is a fat used in emulsification in the preparation of oral pharmaceutical formulations. It has good binding properties, it does not affect tablet hardness and is unaffected by mixing or production parameters. Glyceryl behenate has been investigated for the encapsulation of various drugs such as retinoids. It has also been investigated for use in the preparation of sustained-release tablets;as a matrix-forming agent for the controlled release of water-soluble drugs; It can also be used as a hot-melt coating agent sprayed onto a powder or drug-loaded sugar beads and granules.It may also be incorporated via extrusion/spheronization into pellets, which can be further compressed into tablets.
Application
Glyceryl behenate is used in cosmetics, foods, and oral pharmaceutical formulations. Glyceryl behenate is used in oral enteric-coated pellets, powders and suspensions. It is also used in controlled, extended-release and orally disintegrating tablets. For oral preparations, glyceryl behenate forms a lipidic matrix for sustained-release formulations.
It has been used along with acid-soluble or swellable polymers to mask the bitter or unpleasant taste of the medicament with improved palatability.Glyceryl behenate has been used for the preparation of ophthalmic inserts.
In cosmetics, glyceryl behenate is used as a skin conditioning agent, emollient and viscosity-increasing agent in emulsions. It also improves the heat stability of emulsions and is a gelifying agent for various oils. For topical formulations, it is used as a thickening agent for oily phases. It is also used as a surfactant or emulsifying agent.
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