| Name | 9-amino-CPT |
| Description | 9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. |
| In vitro | 9-amino-CPT inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-amino-CPT cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-amino-CPT concentrations exceed a threshold of 2.7 nM [2]. |
| In vivo | 9-amino-CPT inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-amino-CPT induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.33 mg/mL (9.16 mM)
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| Keywords | Inhibitor | 9 amino CPT | inhibit | 9aminoCPT | 9-amino-CPT | Topoisomerase | 9-amino-2camptothecin |
| Inhibitors Related | Berberine chloride | EIDD-1931 | Flumequine | Levofloxacin hydrochloride | Norfloxacin | Prulifloxacin | Enoxacin | Pefloxacin Mesylate | Ciprofloxacin | Ciprofloxacin monohydrochloride | Levofloxacin | Etoposide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
