DL-Mevalonolactone

Name

DL-Mevalonolactone

Synonym

More Synonyms

Description

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

Related Catalog

References

[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.

[2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.

Density

1.189 g/cm3

Boiling Point

145-150 °C5 mm Hg(lit.)

Melting Point

28 °C(lit.)

Molecular Formula

C6H10O3

Molecular Weight

130.14200

Flash Point

>230 °F

Exact Mass

130.06300

PSA

46.53000

LogP

0.07440

Index of Refraction

n20/D 1.473(lit.)

Storage condition

2-8°C

Stability

Hygroscopic