Product Name: URB754
Synonyms: 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one;6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one;6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;URB754, >=98%;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;URB754
CAS: 86672-58-4
MF: C16H14N2O2
MW: 266.29
EINECS:
Product Categories: Chemical for Research;URB754 is a potent, noncompetitive inhibitor of MGL.;All Inhibitors;Inhibitors;Aromatics;Heterocycles;Research Chemical
Mol File: 86672-58-4.mol
URB754 Structure
URB754 Chemical Properties
Melting point 238-240°C
Boiling point 434.0±48.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
form Off-white solid.
pka 3.76±0.20(Predicted)
Safety Information
MSDS Information
URB754 Usage And Synthesis
Chemical Properties Off-White Solid
Uses URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 and binds weakly to the rat CB1 r
Uses URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
URB754 Preparation Products And Raw materials
China
