Product Name: FALECALCITRIOL
Synonyms: FALECALCITRIOL;(+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol;26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3;9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-;Flocalcitriol;Flocalcitrol;Fulstan;Hornel
CAS: 83805-11-2
MF: C27H38F6O3
MW: 524.58
EINECS:
Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 83805-11-2.mol
FALECALCITRIOL Structure
FALECALCITRIOL Chemical Properties
Safety Information
MSDS Information
FALECALCITRIOL Usage And Synthesis
Description Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.
Originator University of Wisconsin (US)
Uses Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.
Brand name Hornel, Fulstan
Hazard A poison by ingestion.
China
