Product Name: Procaine penicilline G hydrate
Synonyms: afsillin;ampin-penicillin;aquacillin;aquasuspen;avloprocil;benzylpenicillinicacidprocainesalthydrate;abbocillin-dc;crysticillin
CAS: 6130-64-9
MF: C29H40N4O7S
MW: 588.72
EINECS: 612-112-2
Product Categories: Agro-Products;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File: 6130-64-9.mol
Procaine penicilline G hydrate Structure
Procaine penicilline G hydrate Chemical Properties
Melting point 106-110° (with decompn)
density 1.255-1.256
solubility Slightly soluble in water, sparingly soluble in ethanol (96 per cent).
form neat
CAS DataBase Reference 6130-64-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 42/43
Safety Statements 36
RTECS XH9450000
HS Code 2941102000
Toxicity LD50 s.c. in mice: 2.3 g/kg (Soehring)
MSDS Information
Provider Language
Procaine penicilline G hydrate English
Procaine penicilline G hydrate Usage And Synthesis
Chemical Properties White Solid
Uses Procaine penicilline G hydrate is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.
Brand name Duracillin(Lilly); Pfizerpen (Pfizer).
Antimicrobial activity The procaine salt of benzylpenicillin. Poorly soluble (1:200 in water). Administered intramuscularly as a suspension of crystals which slowly dissolve at the site of the injection.
It must not be given intravenously. Intramuscular administration produces a flat sustained plasma concentration of penicillin, which is much lower than that achieved by an equivalent dose of benzylpenicillin, with plasma levels still detectable 24 h later. An injection of 0.6 g yields a peak plasma concentration of 1–2 mg benzylpenicillin/L after 2–4 h. Free procaine is detectable in the plasma within 30 min.
Very severe and potentially fatal reactions resembling those of anaphylactic shock, but non-allergic in character, may occur, probably due to accidental entry into the vascular system at the site of injection and blockage of pulmonary and cerebral capillaries by crystals of the suspension. Reactions due to liberated procaine may include acute anxiety, hypertension, tachycardia, vomiting, audiovisual hallucinations and acute psychotic disturbance. The most severe reactions lead to convulsions and cardiac arrest. Other reactions are those to liberated benzylpenicillin.
China
