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ChemicalBook Product Catalog Taccalonolide A

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Taccalonolide A

$ 9.80 /1KG

Min. Order1KG
Purity＞98%HPLC
Cas No108885-68-3
Supply Ability20 tons
Update time2020-02-07

career henan chemical co

6YR

China

Since2014-12-17

AddressRoom 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H

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Chemical Properties

Product Name	Taccalonolide A
CAS No	108885-68-3
EC-No
Min. Order	1KG
Purity	＞98%HPLC
Supply Ability	20 tons
Release date	2020/02/07

Jessie 785

Contact: jessie@coreychem.com

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[Product Specification】

Names

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Name

Taccalonolide A

Synonym

More Synonyms

Taccalonolide A Biological Activity

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Description

Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3].

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

Target

microtubule[1]

References

[1]. Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20.

[2]. Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9.

[3]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.

Chemical & Physical Properties

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Density

1.4±0.1 g/cm3

Boiling Point

776.8±60.0 °C at 760 mmHg

Molecular Formula

C36H46O14

Molecular Weight

702.742

Flash Point

237.8±26.4 °C

Exact Mass

702.288757

PSA

201.56000

LogP

2.49

Vapour Pressure

0.0±6.1 mmHg at 25°C

Index of Refraction

1.590

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Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;