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ChemicalBook Product Catalog Taccalonolide B

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Taccalonolide B

$ 9.80 /1KG

Min. Order1KG
Purity＞98%HPLC
Cas No108885-69-4
Supply Ability20 tons
Update time2020-02-07

career henan chemical co

5YR

China

Since2014-12-17

AddressRoom 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H

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Chemical Properties

Product Name	Taccalonolide B
CAS No	108885-69-4
EC-No
Min. Order	1KG
Purity	＞98%HPLC
Supply Ability	20 tons
Release date	2020/02/07

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Contact: jessie@coreychem.com

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[Product Specification】

Names

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Name

taccalonolide B

Synonym

More Synonyms

Taccalonolide B Biological Activity

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Description

Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

Target

microtubule[2]

References

[1]. LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28(15): 1673-1675.

[2]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.

Chemical & Physical Properties

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Density

1.4±0.1 g/cm3

Boiling Point

775.9±60.0 °C at 760 mmHg

Molecular Formula

C34H44O13

Molecular Weight

660.705

Flash Point

242.4±26.4 °C

Exact Mass

660.278198

PSA

195.49000

LogP

1.88

Vapour Pressure

0.0±6.0 mmHg at 25°C

Index of Refraction

1.604

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Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;