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Common Name Aminomalonic acid
CAS Number 1068-84-4 Molecular Weight 119.076
Density 1.7±0.1 g/cm3 Boiling Point 402.6±40.0 °C at 760 mmHg
Molecular Formula C3H5NO4 Melting Point N/A
MSDS N/A Flash Point 197.3±27.3 °C
Use of Aminomalonic acid
Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3].
Properties
Spectrum
Names
Name aminomalonic acid
Synonym More Synonyms
Aminomalonic acid Biological Activity
Description Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3].
Related Catalog
Research Areas >> Cancer
Target
Ki: 0.0023 M (L-asparagine synthetase from Leukemia 5178Y/AR), 0.0015 M (L-asparagine synthetase from mouse pancreas)[2]
References
[1]. Van Buskirk JJ, et al. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5.
[2]. Milman HA, et al. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47.
[3]. Kim HY, et al. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Sci Rep. 2017 Aug 18;7(1):8864.
Chemical & Physical Properties
Density 1.7±0.1 g/cm3
Boiling Point 402.6±40.0 °C at 760 mmHg
Molecular Formula C3H5NO4
Molecular Weight 119.076
Flash Point 197.3±27.3 °C
Exact Mass 119.021858
PSA 100.62000
LogP -0.27
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.545
Safety Information
HS Code 2922499990
China
