Product Name: ISOXSUPRINE HYDROCHLORIDE
Synonyms: ISOXSUPRINE HCL;ISOXSUPRINE HYDROCHLORIDE;1-(p-hydroxyphenyl)-2-(1’-methyl-2’-phenoxy)ethylaminopropanol-1hydrochlorid;2-(3-phenoxy-2-propylamino)-1-(p-hydroxyphenyl)-1-propanolhydrochloride;isolait;isoxsuprinhydrochloride;p-hydroxy-alpha-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)-benzylalcohohyd;suprilent
CAS: 579-56-6
MF: C18H24ClNO3
MW: 337.84
EINECS: 209-443-6
Product Categories: VASODILAN;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 579-56-6.mol
ISOXSUPRINE HYDROCHLORIDE Structure
ISOXSUPRINE HYDROCHLORIDE Chemical Properties
Melting point 203-204°
storage temp. 2-8°C
solubility Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in methylene chloride.
pka pKa 8.0 (Uncertain);9.8 (Uncertain)
form neat
CAS DataBase Reference 579-56-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50/53-63-50
Safety Statements 36-61-60
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS DO8225000
HS Code 2922504500
Toxicity LD50 in rats (mg/kg): 1750 orally; 164 i.p. (Goldenthal)
MSDS Information
Provider Language
SigmaAldrich English
ISOXSUPRINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties White Solid
Uses antiepileptic
Uses It is prescribed for the symptomatic relief of cerebrovascular insufficiency and improvement of circulation
Uses As a vasilodator drug, Isoxsuprine Hydrochloride is used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. Isoxsuprine Hydrochloride has been shown to be a β-adrenoreceptor antagonist with β-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. Studies suggest that Isoxsuprine Hydrochloride may be useful as a as a tocolytic agent in the treatment of preterm labour.
Uses vasodilator
Brand name Vasodilan (Apothecon).
Veterinary Drugs and Treatments Isoxsuprine is used in veterinary medicine principally for the treatment of navicular disease in horses; however, recent studies have shown disappointing efficacy when used orally. It has been used in humans for the treatment of cerebral vascular insufficiency, dysmenorrhea, and premature labor, but efficacies are unproven for these indications.
There has been an anecdotal report of isoxsuprine being helpful for treating dogs with a Raynaud’s-like syndrome (periodic digital cyanosis, onychogryphosis) (Carlotti 2002).
China
