Names
Name Corynoline
Synonym More Synonyms
Corynoline Biological Activity
Description Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
Related Catalog
Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE
References
[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.
[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.
Chemical & Physical Properties
Density 1.4±0.1 g/cm3
Boiling Point 504.2±50.0 °C at 760 mmHg
Melting Point 217-218ºC
Molecular Formula C21H21NO5
Molecular Weight 367.395
Flash Point 258.7±30.1 °C
Exact Mass 367.141968
PSA 60.39000
LogP 3.23
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.659
Safety Information
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300 + H330
Precautionary Statements P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Safety Phrases 24/25
RIDADR UN 1544PSN1 6.1 / PGII
Precursor & DownStream
China
