Names
Name Licofelone
Synonym More Synonyms
Licofelone Biological Activity
Description Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor for the treatment of osteoarthritis. Licofelone (ML-3000) exerts anti-inflammatory and anti-proliferative effects. Licofelone (ML-3000) induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2].
Related Catalog
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> COX
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References
[1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.
[2]. Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.
Chemical & Physical Properties
Density 1.2±0.1 g/cm3
Boiling Point 539.7±50.0 °C at 760 mmHg
Melting Point 162-163ºC
Molecular Formula C23H22ClNO2
Molecular Weight 379.879
Flash Point 280.2±30.1 °C
Exact Mass 379.133911
PSA 42.23000
LogP 6.73
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.627
Storage condition -20°C Freezer
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UY7759650
CHEMICAL NAME :
1H-Pyrrolizine-5-acetic acid, 2,3-dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-
CAS REGISTRY NUMBER :
156897-06-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H22-Cl-N-O2
MOLECULAR WEIGHT :
379.91
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,159,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg/11D-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from duodenum
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1329,1994
China
