Product Name: Vinblastine Sulfate
Synonyms: Vinblastine, Vinblastine Sulphate, Vinblastine sulfate salt, Vinblastinum
Molecular Formula: C46H60N4O13S
Molecular Weight: 909.05
CAS NO: 143-67-9
Grade Standard: Pharma Grade
Purity: high purity
Certification: ISO9001, GMP
Quality Specification:USP36 EP7.0
Usage:
It is an anti-cancer drug. it can be used for the treatment of hodgkin's disease and chorio-epithelioma,lymphosarcoma, acute leukemia and breast cancer, etc.
Packaging & Delivery:
10g/bag,20g/bag,50g/bag,100g/bag.
Protect from light, tightly sealed, freezer storage(leiss than -20℃).
Delivery Detail:prompt shipment.
product profile
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Name
Vinblastine sulfate
Other Name
VINBLASTINE SULFATE
CAS No.
143-67-9
EINECS
205-606-0
MF
C46H60N4O13S
MW
909.05
MP
267 °C (dec.)(lit.)
Storage temp.
2-8°C
Purity
99% min
Usage
Antineoplastic agents; API
Appearance
Crystalline Solid
functions
Pharmacology and toxicology Changchun alkali is a kind of alkaloid that has anticancer activity. It mainly inhibits the polymerization of microtubules and prevents the formation of microtubules of the spindle, which stops mitosis in the medium term. It can also be applied to cell membrane, interfering with the transport of amino acids by cell membrane, which can inhibit protein synthesis and inhibit RNA synthesis. Vinblastine antineoplastic spectrum broad, in 0.05 ~ 0.1 mg/kg doses in mice L1210 leukemia, airy, S180 ascites carcinoma, C3H mice spontaneous and metastatic breast cancer have obvious anti-tumor activity, to transplantation in rat cheek pouch of wool also has inhibitory effect on the growth of cancer cells. pharmacokinetic Oral absorption is poor and requires intravenous administration. After the injection of changchun base, it was rapidly distributed in various tissues, rarely penetrating the blood-brain barrier, and the protein binding rate was 75%. Blood was used to remove the drug in two directions, with t1/2 alpha for 4.5 minutes, t1/2 beta for 190 minutes, and the tip elimination phase t1/2 gamma for 24 hours. In the liver, most of it was excreted with bile, and 33% of the drug was excreted in the feces within 3 days after use, mainly metabolites, and 21 percent were excreted with urine. indications Mainly used for the treatment of solid tumors. The efficacy of malignant lymphoma, testicular tumor and choriocarcinoma is better, and it also has some effect on lung cancer, breast cancer, ovarian cancer, skin cancer, renal cell tumor and monocyte leukemia.
Hodgkin's disease and malignant lymphoma can also be used to treat chorionic epithelial carcinoma and breast cancer.
Company profile
Hebei Xibaijie Biotechnology Co., Ltd has a registered capital of 3 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. Now we have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. Also we have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.
After many years of efforts, we have established stable and friendly business relations with many of European and American pharmaceutical companies, multinational chemical companies and importers.At home and many production plants and research and development units have established long - term commission processing and production relations.We have a number of laboratories specializing in technology development and custom synthesis, as well as some production bases, mainly in hebei, dalian, jiangsu and guangzhou.
Our company possesses the right of self-support import & export, a strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards. We put the quality management as the focus of enterprise management, to customer satisfaction for the purpose of the company, in order to ensure the quality of each batch of products to meet customer demand.We by strengthening employee training, improve the detection technology, perfect detection index to improve every aspect of quality control, improve the quality of the products.
China
