CILAZAPRIL

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Product Name:

CILAZAPRIL

Synonyms:

Initiss;Justor;Vascase;9-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-10-oxo-1,2,3,4,6,7,8,9-oc tahydropyridazino[1,2-a]diazepine-1-carboxylic acid;9[[1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6HPYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID;CILAZAPRIL EPC(;CILAZAPRIL EPC(CRM STANDARD);CILAZAPRIL IMPURITY A1,1-DIMETHYLETHYL(1S,9S)-9-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]-10-OXO-OCTAHYDRO-6H-PYRIDAZINO[1,2A][1,2]DIAZEPINE-1-CABOXYLATE EPC

CAS:

92077-78-6

MF:

C22H33N3O6

MW:

435.51

EINECS:

Product Categories:

-;Inhibitors

Mol File:

92077-78-6.mol

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CILAZAPRIL Chemical Properties

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Melting point

98° (dec)

alpha

D20 -62.51° (c = 1% in ethanol)

solubility

Slightly soluble in water, freely soluble in methanol and in methylene chloride.

form

neat

pka

pKa1 3.3; pKa2 6.4(at 25℃)

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CILAZAPRIL Usage And Synthesis

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Description

Cilazapril is a new ACE inhibitor useful in the management of mild to moderate hypertension. Orally administered cilazapril is a prodrug which is de-esterified to its active diacid metabolite cilazprilat. Compared with enalapril and captopril, cilazapril is more potent and longer lasting.

Chemical Properties

White or almost white, crystalline powder.

Originator

Hoffmann-LaRoche (Switzerland)

Uses

Antihypertensive.

Brand name

Inhibace (Hoffmann-LaRoche).

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CILAZAPRIL Preparation Products And Raw materials

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Raw materials

Sodium carbonate-->POTASSIUM BICARBONATE-->Diborane

Product Name	CILAZAPRIL
CAS No	92077-78-6
EC-No
Min. Order	1g
Purity	99%
Supply Ability	200kg
Release date	2020/01/13

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