| Name | 8-Epidiosbulbin E acetate |
| Description | 8-Epidiosbulbin E acetate is a abundant furan compound found in Dioscorea bulbifera L., exhibiting broad-spectrum plasmid elimination activity against multidrug-resistant bacteria, and can be used to induce liver injury models in mice. |
| In vitro | A novel plasmid-curing compound was identified as 8-Epidiosbulbin E acetate (EEA) (norditerpene) on the basis of modern spectroscopic analysis and X-ray crystallography. EEA exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. EEA cured antibiotic resistance plasmids (R-plasmids) from clinical isolates of Enterococcus faecalis, Escherichia coli, Shigella sonnei and Pseudomonas aeruginosa with 12-48% curing efficiency. The reference plasmids of Bacillus subtilis (pUB110), E. coli (RP4), P. aeruginosa (RIP64) and Salmonella typhi (R136) were cured with efficiency ranging from 16% to 64%. EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (141.6 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.15 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Bacterial | Anti-infection | Antiinfection | Antifection | 8-Epidiosbulbin E Acetate | 8Epidiosbulbin E acetate | 8-Epidiosbulbin E | 8 Epidiosbulbin E acetate |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Doxycycline (hyclate) | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Dimethyl sulfoxide | Ethyl acetoacetate | Ampicillin |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Bacterial Compound Library | NO PAINS Compound Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library |
United States
