Geissoschizine methyl ether

Name

Geissoschizine methyl ether

Synonym

More Synonyms

Description

Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist[1][2].

Related Catalog

Target

5-HT1A[2]

References

[1]. Matsumoto T, et al. In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan. Xenobiotica. 2016;46(4):325-34.

[2]. Nishi A, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012 Apr 5;207:124-36.

Density

1.2±0.1 g/cm3

Molecular Formula

C22H26N2O3

Molecular Weight

366.45300

Exact Mass

366.19400

PSA

54.56000

LogP

3.67450