9-Methoxycamptothecin

Name

9-Methoxycamptothecin

Synonym

More Synonyms

Description

9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].

Related Catalog

Target

Topoisomerase[1]. Apoptosis[2].

References

[1]. Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66(9-10):471-6.

[2]. Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.

Density

1.5±0.1 g/cm3

Boiling Point

773.1±60.0 °C at 760 mmHg

Melting Point

223-225 ºC

Molecular Formula

C21H18N2O5

Molecular Weight

378.378

Flash Point

421.4±32.9 °C

Exact Mass

378.121582

PSA

90.65000

LogP

2.00

Vapour Pressure

0.0±2.8 mmHg at 25°C

Index of Refraction

1.723

Water Solubility

Slightly soluble (2.7 g/L) (25 ºC)