Product Name: Bis(maltolato)oxovanadium(IV)
Synonyms: BMOV;BIS(MALTOLATO)OXOVANADIUM(IV);oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate);BIS(MALTOLATO)OXOVANADIUM;(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM
CAS: 38213-69-3
MF: C12H10O7V
MW: 317.15
EINECS:
Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 38213-69-3.mol
Bis(maltolato)oxovanadium(IV) Structure
Bis(maltolato)oxovanadium(IV) Chemical Properties
Melting point >300°C (dec.)
storage temp. Refrigerator
form powder
color yellow to grey to brown
Safety Information
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
Bis(maltolato)oxovanadium(IV) Usage And Synthesis
Chemical Properties Dark Purple Solid
Uses It is a potent insulin mimic. Results showed that a promising outlook as an oral glucose-lowering drug.
Pharmaceutical Applications Bis(maltolato)oxovanadium (BMOV) has proven itself as a successful antidiabetic agent when tested in animalmodels. Nevertheless, only very little is known about its mode of action. It is believed that BMOV acts as a competitive and reversible inhibitor of the enzyme protein tyrosine phosphatase (PTP).
As previously mentioned, BMOV is believed to be a potent and competitive inhibitor of the PTP1B activity and additionally seem to support the autophosphorylation of the insulin receptor leading to an increased sensitivity towards insulin. Research has shown that varying the organic ligand has an influence on the effectiveness and bioavailability of the resulting vanadium compound. It is believed that factors such as absorption, tissue uptake and distribution are affected most. Interestingly enough, X-ray crystal data of PTP1B soaked with BMOV showed only vanadate [V(+V)O43?] at the active site. This would emphasise that the organic ligands are only carriers of the active compound and play no role in the enzyme inhibition itself. Furthermore, in aqueous solution, V(IV) is rapidly and reversibly oxidised to V(V), supporting the possible formation of vanadate.
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