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Mezlocillin

$ 1.00 /1KG

Min. Order1KG
Purity99%
Cas No51481-65-3
Supply Ability10000KGS
Update time2020-01-01

career henan chemical co

5YR

China

Chemical Properties

Product Name	Mezlocillin
CAS No	51481-65-3
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	10000KGS
Release date	2020/01/01

hanne 774

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Product Name:

Mezlocillin

Synonyms:

(2s-(2-alpha,5-alpha,6-beta)(s*))-sodiumsal;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-6-(((((3-(met;3,3-dimethyl-7-[[2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl]amino]-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid;MEZLOCILLIN;Melocillin sodium;antibioticbay-f1353;Meloxacam acid;Mezlocillin acid

CAS:

51481-65-3

MF:

C21H25N5O8S2

MW:

539.58

EINECS:

257-233-8

Product Categories:

Mol File:

51481-65-3.mol

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Mezlocillin Chemical Properties

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density

1.63±0.1 g/cm3(Predicted)

pka

pKa 2.7 (Uncertain)

CAS DataBase Reference

51481-65-3(CAS DataBase Reference)

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Safety Information

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MSDS Information

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Mezlocillin Usage And Synthesis

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Uses

Antibacterial.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.

Brand name

Multocillin (Bayer).

Antimicrobial activity

A semisynthetic acylureidopenicillin supplied as the sodium salt for parenteral administration.
Ampicillin-susceptible strains of H. influenzae and Neisseria spp. are very susceptible, but β-lactamase-producing organisms are usually resistant. It is less active than azlocillin and piperacillin against Ps. aeruginosa and has variable activity against B. fragilis, independent of β-lactamase production. It exhibits typical β-lactam synergy with aminoglycosides against Ps. aeruginosa and enterobacteria.
It attains peak concentrations of 250 mg/L after a 2 g intravenous infusion, with a plasma half-life of 55 min. Protein binding is 20–30%. It distributes into multiple tissues and human body fluids at therapeutically useful concentrations. Up to 60% of the dose is recoverable unchanged from the urine, with up to 2.5% excreted in the bile.
Toxicity and side effects are similar to those associated with carboxypenicillins. Its clinical use is for serious infections with susceptible organisms, including lower respiratory tract, intra-abdominal, urinary tract and gynecological infections. Commercial availability is quite limited.

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