Chemical Properties
A light-yellow to white antibiotic produced by Streptomyces niveus. Available as calcium and sodium salts.
Uses
Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Uses
Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive antibiotic activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Definition
ChEBI: A coumarin-derived antibiotic obtained from Streptomyces niveus.
World Health Organization (WHO)
Novobiocin, an antibiotic with a narrow spectrum of activity, was introduced in 1956. Its use was subsequently associated with serious adverse effects including blood dyscrasias. In view of its toxicity there are no current valid indications for its use. Although preparations containing novobiocin may remain available in some countries it has largely lapsed into disuse.
Hazard
May have damaging side effects.
Veterinary Drugs and Treatments
Novobiocin is approved as a single agent and in combination with penicillin G for use in dry dairy cattle as a mastitis tube. Novobiocin is available in combination with tetracycline and prednisolone for oral use in dogs.
China
