Factory high quality and low price APHIDICOLIN | China | Manufacturer

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APHIDICOLIN Basic information

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Product Name:

APHIDICOLIN

Synonyms:

InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem;Aphidicolin - CAS 38966-21-1 - Calbiochem;(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol;APHIDICOLIN FROM CEPHALOSPORIUM APHIDICO LA;APHIDICOLIN FROM NIGROSPORA SPHAERICA;8,11a-Methano-11aH-cycloheptaanaphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-;Aphidicolin, froM Nigrospora oryzae;Aphidicolin NSC 234714 ICI 69653

CAS:

38966-21-1

MF:

C20H34O4

MW:

338.48

EINECS:

609-602-3

Product Categories:

Di-Terpenoids;antibiotic

Mol File:

38966-21-1.mol

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APHIDICOLIN Chemical Properties

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Melting point

218-220°C

alpha

D27 +12° (c = 1 in methanol)

Boiling point

394.61°C (rough estimate)

density

1.0057 (rough estimate)

vapor pressure

0.55 hPa ( 20 °C)

refractive index

1.4434 (estimate)

87℃

storage temp.

2-8°C

solubility

ethanol: soluble1mg/mL (stable at least a week at 4°C.)

pka

14.24±0.70(Predicted)

form

White solid

color

colorless

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

Water Solubility

Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°

Merck

13,734

BRN

4689958

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Safety Information

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Safety Statements

22-24

RIDADR

NA 1993 / PGIII

WGK Germany

RTECS

PB9185000

10-21

HS Code

29419090

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MSDS Information

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Provider

Language

SigmaAldrich

English

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APHIDICOLIN Usage And Synthesis

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Chemical Properties

White crystal

Uses

(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.

Uses

Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumour agents, vincristine and doxorubicin.

Uses

Definition

ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.

Product Name	APHIDICOLIN
CAS No	38966-21-1
EC-No	609-602-3
Min. Order	1g
Purity	≥98%
Supply Ability	g/kg/Ton
Release date	2019/12/26

APHIDICOLIN

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