ChemicalBook Product Catalog ALAMETHICINRESEARCH GRADE

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ALAMETHICINRESEARCH GRADE

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Min. Order1g
Purity≥98%
Cas No27061-78-5
Update time2019-12-26

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Chemical Properties

Product Name	ALAMETHICINRESEARCH GRADE
CAS No	27061-78-5
EC-No	608-040-6
Min. Order	1g
Purity	≥98%
Release date	2019/12/26

Heidi 0647

Email:heidi@coreychem.com

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ALAMETHICINRESEARCH GRADE Basic information

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Product Name:

ALAMETHICINRESEARCH GRADE

Synonyms:

N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1;Alamethicin, Ready Made Solution;ALAMETHICINRESEARCH GRADE;alamethicin from trichoderma viride;Almethicin, Antibiotic U-22324, 6-(2-methylalanine)-8-L-leucine-9-de-L-valine-12-(2-methylalanine)-13a-endo-(2-methylalanine)-18-L-glutamine-19-(N(1)-(1-(hydroxymethyl)-3-methylbutyl)-L-glutamamide)-];Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol;(3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-AcetaMido-2-Methylpropanoyl)pyrrolidin-2-yl)-15-(3-aMino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecaMethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,1;Peptaibol coMplex. Additional synonyMs for the Major coMponent, alaMethicin I: AlaMethicin F30, AlaMethicin-gaMMa, U 22324

CAS:

27061-78-5

MF:

C92H150N22O25

MW:

1964.3078

EINECS:

608-040-6

Product Categories:

Ion transporter and other ion channel;antibiotic

Mol File:

27061-78-5.mol

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ALAMETHICINRESEARCH GRADE Chemical Properties

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87℃

storage temp.

2-8°C

form

DMSO solution

BRN

5213858

Stability:

Stable.

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Safety Information

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Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 3462 6.1/PG 3

WGK Germany

10-21

HS Code

29419090

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MSDS Information

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ALAMETHICINRESEARCH GRADE Usage And Synthesis

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Chemical Properties

solid

Uses

Alamethicin is an acidic linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids”, with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F30 acts an ionopohore, transporting ions through membranes and artificial lipid membranes and forming voltage-dependent ion channels in lipid bilayer membranes. Alamethicin is co-produced with a parallel, neutral, linear peptaibol complex (alamethicin F50). The relative composition of alamethicin is a variable mixture of the acidic and neutral complexes, but reports on alamethacin do not generally specify the ratio of F50 to F30, and comparative data between the complexes is scant.

Uses

Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.

Purification Methods

Recrystallise alamethicin from MeOH. [Panday et al. J Am Chem Soc 99 8469 1977.] The acetate has m 195-180o from MeOH/Et2O, and the acetate-methyl ester [64936-53-4] has m 145-140o from aqueous MeOH.

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