LY 344864

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Product Name:

LY 344864

Synonyms:

LY 344864;LY 344864 hydrochloride;N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride;(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride;(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide;LY344864 HCL

CAS:

186544-26-3

MF:

C21H22FN3O

MW:

351.423

EINECS:

Product Categories:

Inhibitors

Mol File:

186544-26-3.mol

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LY 344864 Chemical Properties

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Boiling point

471.9±45.0 °C(Predicted)

density

1.28±0.1 g/cm3(Predicted)

storage temp.

Store at +4°C

pka

14.12±0.40(Predicted)

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Safety Information

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MSDS Information

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LY 344864 Usage And Synthesis

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Biological Activity

Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

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LY 344864 Preparation Products And Raw materials

Product Name	LY 344864
CAS No	186544-26-3
EC-No
Min. Order	1g
Purity	99.99%
Supply Ability	200kg
Release date	2019/12/25

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