Manidipine

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Product Name:

Manidipine

Synonyms:

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester;Manidipine;Manidipine(CV-4093);2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester;2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;89226-75-5 (Di-hydrochloride);1-diphenylmethyl-4-(2-hydroxyethyl)piperazine

CAS:

89226-50-6

MF:

C35H38N4O6

MW:

610.7

EINECS:

1806241-263-5

Product Categories:

Dihydropyridine;Artedil, Iperten;Inhibitors;Dihydropyridine Class Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals

Mol File:

89226-50-6.mol

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Manidipine Chemical Properties

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Melting point

125-128°C

Boiling point

722.0±60.0 °C(Predicted)

density

1.232±0.06 g/cm3(Predicted)

storage temp.

-20°C Freezer

pka

6.12±0.10(Predicted)

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Safety Information

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MSDS Information

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Manidipine Usage And Synthesis

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Chemical Properties

Light Yellow Crystalline Solid

Uses

A dihydropyridine calcium channel blocker. Antihypertensive

Uses

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

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Manidipine Preparation Products And Raw materials

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Raw materials

Magnesium sulfate-->Isopropyl ether-->Acetyl ketene-->Methyl 3-aminocrotonate-->N-(2-Hydroxyethyl)piperazine-->Manidipine hydrochloride-->Manidipine

Product Name	Manidipine
CAS No	89226-50-6
EC-No
Min. Order	1g
Purity	99.99%
Supply Ability	200kg
Release date	2019/12/24

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