| Name | 7,4'-Dihydroxyflavone |
| Description | 7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2. |
| In vitro | Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (983.32 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.67 mM), Sonication is recommended.
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| Keywords | Nuclear factor-κB | Nuclear factor-kappaB | NOD1 | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | HDAC2 | COX | CCR | CC chemokine receptor | 7,4'-Dihydroxyflavone | 7,4'Dihydroxyflavone | 7,4' Dihydroxyflavone |
| Inhibitors Related | Naringin dihydrochalcone | Valproic acid sodium salt | Sodium 4-phenylbutyrate | Acetaminophen | Aspirin | Valproic Acid | Curcumin | Glucosamine | Gallic Acid Monohydrate | N,N-Dimethylacetamide | Paradol | Salicylic acid |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Bitter Compound library | Anti-infective Natural Product Library | Immunology/Inflammation Compound Library | Ancient Chinese Classical Formulas Compound Library |
United States
