ChemicalBook Product Catalog Biochemical Engineering Inhibitors Apoptosis PERK activator SALUBRINAL

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SALUBRINAL

$ 1.00 /1KG

Min. Order1KG
Purity99%
Cas No405060-95-9
Supply Ability100kgs
Update time2019-12-20

career henan chemical co

5YR

China

Chemical Properties

Product Name	SALUBRINAL
CAS No	405060-95-9
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	100kgs
Release date	2019/12/20

Mary 0010

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Product Name:

SALUBRINAL

Synonyms:

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-;(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal;Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide;N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide;3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE;(E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea

CAS:

405060-95-9

MF:

C21H17Cl3N4OS

MW:

479.81

EINECS:

Product Categories:

Inhibitors;Apoptosis Inhibitors;-

Mol File:

405060-95-9.mol

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SALUBRINAL Chemical Properties

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density

1.474±0.06 g/cm3(Predicted)

storage temp.

Store at +4°C

solubility

DMSO: soluble20mg/mL, clear

form

powder

pka

10.70±0.70(Predicted)

color

, white to light yellow to light gray

Water Solubility

Insoluble in water.

Sensitive

Light Sensitive

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Safety Information

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Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

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MSDS Information

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SALUBRINAL Usage And Synthesis

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Description

Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal can protect PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM) and prevent replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is also being studied for its effects in osteoporosis. Besides, it also shows potential neuroprotective actions. Although salubrinal has putative therapeutic value due to its function, it is as yet only used experimentally.

References

1. https://en.wikipedia.org/wiki/Salubrinal
2. http://www.sigmaaldrich.com/catalog/product/sigma/sml0951?lang=en&region=CA
3. https://www.tocris.com/dispprod.php?ItemId=143907#.WQfadeyECP0
4. http://www.selleckchem.com/products/salubrinal.html
5. https://www.caymanchem.com/product/14735
6. https://www.hellobio.com/salubrinal.html

Uses

Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons

Definition

ChEBI: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective in ibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).

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SALUBRINAL Preparation Products And Raw materials

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