3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide | China | Manufacturer

Mary 0003

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Product Name:

IWR-1-endo

Synonyms:

rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo;IWR-1-endo, >=98%;IWR-1(IWR-1-endo);4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide (IWR-1);[(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide;endo-IWR 1;IWR-1-endo - IWR-1 | endo-IWR-1;IWR-1

CAS:

1127442-82-3

MF:

C25H19N3O3

MW:

409

EINECS:

Product Categories:

Inhibitors;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals

Mol File:

1127442-82-3.mol

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IWR-1-endo Chemical Properties

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alpha

-3.0～+3.0°(20℃/D)(c=0.1,CH3CN)

Boiling point

643.9±55.0 °C(Predicted)

density

1.425±0.06 g/cm3(Predicted)

storage temp.

Store at RT

solubility

DMSO: soluble5mg/mL, clear

form

Liquid

pka

11.88±0.43(Predicted)

color

white to beige

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Safety Information

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WGK Germany

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MSDS Information

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IWR-1-endo Usage And Synthesis

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Uses

IWR-1-endo act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosi s.

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IWR-1-endo Preparation Products And Raw materials

Product Name	IWR-1-endo
CAS No	1127442-82-3
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	100kgs
Release date	2019/12/20

IWR-1-endo

Company Profile Introduction

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