| Name | 7-Methoxyflavone |
| Description | 7-Methoxyflavone isolated from Zornia brasiliensis with antinociceptive effects. |
| In vivo | The antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID?? = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.93 mM), Sonication is recommended.
DMSO : 25 mg/mL (99.1 mM), Sonication is recommended.
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| Keywords | peripheral antinociceptive | paw-licking time | Inhibitor | inhibit | inflammatory | 7-Methoxyflavone | 7Methoxyflavone | 7 Methoxyflavone |
| Inhibitors Related | Tebuconazole | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | Naringin | Tauroursodeoxycholate | Dibenzothiophene | Clarithromycin | Memantine hydrochloride |
| Related Compound Libraries | Flavonoid Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | NO PAINS Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
