Streptomycin sulfate is an aminocyclitol glycoside antibiotic which interferes with protein synthesis in prokaryotes.
This Streptomycin sulfate antibiotic is effective against both gram-positive and gram-negative bacteria and is frequently used in cell culture media.
Streptomycin inhibits protein synthesis by binding to the 30S ribosomal subunit at the S12 protein thereby inducing a misreading of the genetic code, inhibiting the initiation of translation of DNA which then results in death for a susceptible bacterium.
Certificate of Analysis
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Item
Specification
Specific rotation
+39.5 to +41.5°
State of solution(transmittance)
Clear 98.0% min.
Chloride[cl]
0.020% max.
Ammonium [NH4]
0.02% max.
Sulfate[SO4]
0.020% max
Iron[Fe]
10ppm max.
Heavy metals [Pb]
10ppm max
Arsenic[As2O3]
1ppm max
Other amino acids
Chromatographically not detectable
Loss on drying
0.20% max.
Residue on ignition[sulfated]
0.10% max.
Assay
99.0% min
Functions
Functions
An antibiotic produced by the soil actinomycete Streptomyces griseus. Streptomyces acts by inhibiting the initiation and elongation processes during protein synthesis. For tularemia, plague, brucellosis and glanders serious treatment (often combined with tetracycline or chloramphenicol). Also used second-line treatment of TB and multi-combination with other anti-TB drugs.
Application
Application
Streptomycin sulfate as an aminoglycoside antibiotic drugs.Streptomycin sulphate of n/med tuberculosis bacili have strong antibacterial effect, for most gram-positive cocci (such as all kinds of streptococcus pneumoniae) and bacillus (e.g., pseudomonas aeruginosa, anaerobic bacteria) antibacterial effect is not strong, for many gram-negative bacilli has strong antimicrobial effect, tuberculosis is effective to all kinds of skin, inhibiting the bacteria and toxins produced by function, high concentration (> 0.4 mu g/mL) have antiseptic effect.N/med tuberculosis bacili of streptomycin resistance quickly, should be associated with other anti-tuberculosis medicine application.
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