- 6,7-Isoquinolinediol, 3,4-dihydro-hydrobromide (1:1) is a chemical compound with the molecular formula C9H10BrNO2 and the molecular weight 244.09 g/mol.
- It is a white to off-white crystalline powder that is soluble in water and ethanol.
- It is an intermediate for the synthesis of **deutetrabenazine**, a deuterated derivative of tetrabenazine .
- Deutetrabenazine is a drug that inhibits the vesicular monoamine transporter 2 (VMAT2), which regulates the levels of dopamine, norepinephrine and serotonin in the body.
- Deutetrabenazine is approved by the FDA for the treatment of chorea associated with Huntington's disease and tardive dyskinesia in adults.
- Deutetrabenazine has a longer half-life and improved pharmacokinetic profile than tetrabenazine, due to the substitution of hydrogen atoms with deuterium atoms on the methoxy groups of the phenyl ring, which slows down the metabolic oxidation of the drug .
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