Nimorazole

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Nimorazole Basic information

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Product Name:

Nimorazole

Synonyms:

4-[2-(5-Nitroimidazol-1-yl)ethyl]morpholine;4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine;K-1900;Naxogin;Nitrimidazine;Nulogyl;1-(2-N-Morpholinylethyl)-5-nitroimidazole;Acterol

CAS:

6506-37-2

MF:

C9H14N4O3

MW:

226.23

EINECS:

229-394-4

Product Categories:

-;API;Inhibitors

Mol File:

6506-37-2.mol

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Nimorazole Usage And Synthesis

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Uses

Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa.

Pharmaceutical Applications

An orally administered 5-nitroimidazole. It is slightly soluble in water at room temperature, soluble in alcohols, acetone and chloroform. The spectrum includes T. vaginalis, G. lamblia, E. histolytica, anaerobic bacteria and G. vaginalis. Activity against B. fragilis and Fusobacterium spp. is similar to or slightly less than that of metronidazole (mean MIC 0.25–1 mg/L).
A peak blood concentration of about 32 mg/L occurs within 2 h of a 500 mg oral dose. High concentrations are achieved in saliva and vaginal secretions. Excretion is principally via the urine where the drug appears as metabolites which display antimicrobial and antiprotozoal activity less than that of the parent drug.
It is generally well tolerated even at the high doses required in conjunction with radiotherapy for the treatment of head and neck tumors. Adverse effects are the same as those of metronidazole. Disulfiram-like reactions appear to be rare.
Clinical uses are similar to those of metronidazole. It is also used as a hypoxic radiosensitizer in the radiotherapy of head and neck tumors.

Product Name	Nimorazole
CAS No	6506-37-2
EC-No
Min. Order	1KG
Purity	95%
Supply Ability	2kg
Release date	2019/09/06

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