METHYL 4-AMINOSALICYLATE

$ 1.00 /1KG

Min. Order1KG
Purity99%
Cas No4136-97-4
Supply AbilityCustomized
Update time2019-07-06

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Chemical Properties

Product Name	METHYL 4-AMINOSALICYLATE
CAS No	4136-97-4
EC-No	223-958-3
Min. Order	1KG
Purity	99%
Supply Ability	Customized
Release date	2019/07/06

SP476

METHYL 4-AMINOSALICYLATE Basic information

Product Name:	METHYL 4-AMINOSALICYLATE
Synonyms:	Methyl 4-aminosalicylate, 3-Hydroxy-4-(methoxycarbonyl)aniline, 5-Amino-2-(methoxycarbonyl)phenol;Methyl 4-amino-2-hydroxybenzoate 97%;Benzoic acid,4-aMino-2-hydroxy-, Methyl ester;Methyl 4-aMino-2-hydroxybenzenecarboxylate, >95%;4-AMINOSALICYLATE;METHYL 4-AMINO-2-HYDROXYBENZOATE;P-AMINO METHYL SALICYLATE;4-amino-2-hydroxy-benzoicacimethylester
CAS:	4136-97-4
MF:	C8H9NO3
MW:	167.16
EINECS:	223-958-3
Product Categories:	-
Mol File:	4136-97-4.mol

METHYL 4-AMINOSALICYLATE Chemical Properties

Melting point	120-123°C
density	1.305±0.06 g/cm3 (20 ºC 760 Torr)
form	Powder
Water Solubility	Slightly soluble in water.
λmax	254nm(lit.)
CAS DataBase Reference	4136-97-4(CAS DataBase Reference)

Safety Information

RTECS	VO1683000
HazardClass	IRRITANT

MSDS Information

METHYL 4-AMINOSALICYLATE Usage And Synthesis

Enzyme inhibitor

This aromatic acid (FWfree-acid = 153.14 g/mol: CAS 2066-89-9; Abbreviation: PAS), also known by the trade name Paser? as well as 4- aminosalicylic acid or p-aminosalicylic acid, is an analogue of p- aminobenzoate, an essential intermediate in the bacterial folate synthesis. PAS potently inhibits the growth of Mycobacterium bovi, M. smegmatis, and M. tuberculosis. It is also used for the treatment of such inflammatory bowel diseases as ulcerative colitis and Crohn's disease, most likely by inhibiting NF-kB. Primary Mode of Antimicrobial Action: Although in use clinically for over 60 years, p-aminosalicylate’s inhibitory mechanism had proved elusive. Recent studies, however, demonstrated that PAS is prodrug, one that targets dihydrofolate reductase, or DHFR. PAS is first converted by dihydropteroate synthase (DHPS) a nd dihydrofolate synthase (DHFS) to a hydroxyl-dihydrofolate antimetabolite, which in turn inhibits DHFR. PAS is about as efficient a DHPS substrate as its natural substrate pABA, and inhibition of DHPS or mutation in DHFS prevents the formation of the antimetabolite and confers resistance to PAS.

METHYL 4-AMINOSALICYLATE Preparation Products And Raw materials

Preparation Products

Methyl 4-acetamido-2-methoxybenzoate-->4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide-->METHYL 4-ACETAMIDO-2-METHOXYBENZOAT

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