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ChemicalBook Product Catalog Satraplatin

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Satraplatin

$ 7.00 /1KG

Min. Order1KG
Purity99%
Cas No129580-63-8
Supply Ability200KG
Update time2019-07-06

career henan chemical co

career henan chemical co

6YR

China

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Chemical Properties

Product Name	Satraplatin
CAS No	129580-63-8
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	200KG
Release date	2019/07/06

JD607

Product Name:	Satraplatin
Synonyms:	bis(acetato-o)amminedichloro(cyclohexanamine)-pt;platinum (lv) cis-dichloro-trans-bis(acetato-o)ammine(cyclohexanamine);SATRAPLATIN;JM 216;Bis-acetatoamminedichlorocyclohexylamine platinum(iv);C081294;Platinum, bis(acetato-o)amminedichloro(cyclohexanamine)-, (oc-6-43)-;Satraplatin(JM216)
CAS:	129580-63-8
MF:	C10H22Cl2N2O4Pt
MW:	500.28
EINECS:
Product Categories:	Anticancer
Mol File:	129580-63-8.mol

Satraplatin Chemical Properties

Safety Information

Toxicity

LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland)

MSDS Information

Satraplatin Usage And Synthesis

Uses	Antineoplastic.
Definition	ChEBI: A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.
Pharmaceutical Applications	Satraplatin (JM216, cis,trans,cis-[PtCl2(OAc)2(NH3)(C6H5NH2)]) is a Pt(IV) or Pt4+ complex, which is active by oral administration, as it is more hydrophobic than cisplatin. This form of administration is very attractive because of the convenience and freedom it provides to the patient. Satraplatin also has a milder toxicity profile and is shows no cross-resistance with cisplatin. Satraplatin in combination with prednisone has completed phase III clinical trials against hormone-refractory prostate cancer. The results were very encouraging, but the overall survival rate did not improve significantly enough. As a result, the fast-track approval of the FDA was not granted. Structurally, satraplatin consists of a Pt(IV) centre, which is coordinated by six ligands forming a close to octahedral geometry. In general, octahedral Pt(IV) complexes (low-spin d6) are much more kinetically inert than square planar Pt(II) complexes.

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