| CAS: | 19916-73-5 |
| MF: | C12H11N5O |
| MW: | 241.25 |
| EINECS: | 1592732-453-0 |
| Product Categories: | Alkylguanine-DNA alkyltransferase, mammalian DNA repair proteinApoptosis and Cell Cycle;DNA Repair Regulators;Nucleotides and Nucleosides;A to;DNA metabolism;Enzyme Inhibitors by Enzyme;Bases & Related Reagents;Nucleotides |
| Mol File: | 19916-73-5.mol |
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| 6-O-Benzylguanine Chemical Properties |
| Melting point | 193(dec.) |
| Boiling point | 459.3±55.0 °C(Predicted) |
| density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | methanol: 20 mg/mL |
| pka | 7.47±0.20(Predicted) |
| form | solid |
| color | Off-White to Light Yellow |
| CAS DataBase Reference | 19916-73-5(CAS DataBase Reference) |
| 6-O-Benzylguanine Usage And Synthesis |
| Chemical Properties | Light Yellow Solid |
| Uses | An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents. |
| Uses | O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. |
| Biochem/physiol Actions | O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma. |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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